In my last blog, I talked about Soft Tissue Calcification (STC) and its link to many diseases. Basically, STC is a process in which calcium binds with phosphorus in places of the body other than bone and teeth. The formation of these calcium “crystals” has a substantial impact on the tissues wherein it is formed.
This impact is multifaceted and affects not only the physical characteristics of the tissues, such as hardening and loss of flexibility but it also provides an active substrate to attract calcium binding proteins (>3000 in your body) and activate them. Some calcium binding proteins include those that can cause inflammation and thrombosis…the hallmarks of atherosclerosis and other heart conditions. Other manifestations of STC are easier to see and feel, such as kidney, salivary and gall stones.
As discussed previously, research is accumulating that proves STC is a cause, not a by product ,of pathology. For example, research by Nadra et al. published in 2006 by the American Heart Association showed that basic calcium phosphate crystals (STC) induce inflammation, Dalbeth et al. in 2005 showed inflammation and tissue damage in STC crystal deposition disease, McCarthy et al. in 1998 showed STC crystal induced activation of fibroblasts, and so on.
Considering the link between STC and disease, and considering that more than half of the people in the USA today have some degree of STC, the health savings that we as a country could realize by treating STC early on are in the billions of dollars.
Considering that the medical community is just now becoming aware of the dangers of STC, tools for diagnosing STC are somewhat limited. Existing diagnostic tools include radiological scans such as electron beam computed tomography (EBCT), sonogram, Xray, etc. Promising new technologies are in the works that include novel assays such as ELISA tests.
Treatment of STC has historically followed the rule that if you control the amount of calcium and phosphorus in the body, then you can control the degree of calcium phosphate precipitation in the soft tissues. This protocol may be appropriate for dire situations wherein the patient is in dire need, such as those with end stage renal disease (ESRD). ESRD patients calcify very quickly, partly due to intense dialysis, and are treated with powerful phosphate binders such as selevamer HCL.
Bisphosphonates, osteoporosis drugs, are under investigation as a possible compounds to de-calcify soft tissues when administered correctly, presumably due to their ability to bind to calcium or hydroxyapatite within the bone matrix.
EDTA, ethylene di-amine tetraacetic acid, is also used by some physicians in Chelation Therapy. Chelation therapy has been around for decades and intends to remove calcium crystals from the soft tissues by grabbing calcium from the crystals and carrying it to the excretory system.
Other compounds that appear in the literature as inhibitors of STC include pyrophosphate, magnesium, citrate, glycosaminoglycans, Nephrocalcin, and, more recently, vitamin K2 (menaquinone 7). Also, some suggest that simple antioxidant compounds may help reduce the risk of calcification.
It would seem logical that combination of protocols, available over the counter, may be a good way to get control of STC before it gets out of control. If most people have some degree of STC by the age of 50, then a slow, mindful approach would be warranted…by everyone!
A step wise approach to your health with regards to STC looks like this….1) attempt to clear as many calcium crystals as possible from the soft tissues using established compounds such as EDTA, citrates, vitamin C, NAC, chlorophyll, etc. 2) make sure the proteins that control calcium are healthy and functional, 3) make sure you get enough minerals such as magnesium and potassium, 4) take a reasonable dose of antioxidants.
Since my last blog, I found a number of websites that have information and/or products that claim to address calcification. I have not personally tried all of these products, nor do I recommend any one site or product specifically…however the following links may be helpful in figuring out if this sort of prevention or treatment is right for you.
http://www.rad.washington.edu/mskbook/softtissueca.html
http://www.nanobaclabs.com/content/calcification.htm
http://calgenex.com/calciclear.html
http://www.medcyclopaedia.com/library/topics/volume_vii/c/calcification_soft_tissue.aspx
http://www.cal-detox.com/system.html
http://www.medscape.com/viewarticle/518757_4
Wishing you a happy and healthy life!
Tuesday, May 8, 2007
Wednesday, April 25, 2007
Is Calcification the CAUSE of Heart Disease?
Calcium deposits in soft tissue (Soft Tissue Calcification, STC) are well known phenomena in the medical world. Unlike healthy calcification that is responsible for bones and teeth, STC is associated with numerous diseases and conditions that pose serious health concerns. The medical community, in general, has known about soft tissue calcification (STC) for more than a century. Surgeons see it when they cut, radiologists see it on X ray films and CT scans, and we see and feel it’s effects in kidney and gall stones. However, even in light of recent compelling evidence, the medical community doesn’t seem to be doing anything about it.
Historically, health care practitioners have mainly considered the process of STC to be passive and secondary to many of the disease in which it is associated. Mounting research, however is begging to paint a new picture wherein STC may actually be the cause of many diseases. A recent study by the Department of Nephrology and Clinical Immunology in Aachen, Germany states that “calcification at unwanted tissue sites leads to dysfunction, disease and, potentially, to death and therefore requires prevention and treatment.” Why?
The health harards regarding STC are not limited to the fact that calcium phosphate deposition hardens our soft tissues, making them rigid and sometimes painful as in arthritis, but also that the calcium phosphate matrix is literally a bioactive substrate laying in wait to turn on some of your bodies most dangerous proteins and to use them against you.
Consider this: there are over 3000 calcium binding proteins in your body that travel through the circulatory and lymphatic system. These proteins rely on the binding of calcium in order to become active and perform its specific function. Many of these calcium binding proteins have extremely important tasks including precursors for inflammation, clotting, and other immunologic functions. The first large scale proteomic mapping of atherosclerotic plaques was recently completed at the University of Connecticut. The study, due to publish in May 2007, is reported to show various new proteins associated with plaque.
A recent study conducted at Baylor College, Department of Medicine, TX wherein researchers evaluated carotid plaque showed a direct correlation between the degree of calcification of the plaque and the proteins therein. Basically, they proved that the more calcification, the more proteins. A study published by the American Heart Association showed, definitively, the active inflammatory response by macrophages to basic calcium phosphate crystals and its implications for atherosclerosis and pathogenesis. Still another study from 2005 linked elevated calcium phosphate (calcification) to elevated High C-reactive protein (common marker for inflammation) concentrations in 47 uremic patients.
STC has been linked to many disease states, including: Alzheimer’s, Arthritis, Bone spurs, Breast calcification, Calcinosis cutis (calcium deposits in the skin), Cancer (bone, brain, breast, colon, prostate, and ovarian), Cataracts, Deafness from middle ear ossification, Diabetes, Gallstones, Glaucoma, Heart disease, notably arteriosclerosis and atherosclerosis, Kidney stones, cysts, polycystic kidney disease (PKD), Liver cysts, Macular degeneration, Meniere’s disease, Prostatitis, Psoriasis, Salivary gland stones, Sclerderma (hardening of the skin), Stroke, Tendinitis.
So why has the link between Calcification and inflammation/disease state not been addressed more aggressively in this country?
Perhaps it’s due to the inherent resistance within the medical community to change, or that a large Pharma company has not spent billions on marketing a drug to address STC? Perhaps it’s the fact that medical science may not know how to address STC?
Regardless, there ARE steps one can take to help address STC, and the most headway in this area seems to be taking place in the realm of dietary supplements.
Available, packaged treatments for soft tissue calcification are relatively rare right now; however there are a couple companies that offer treatments. They range from compounded pharmaceuticals to specialty, condition specific dietary supplements. A handful of companies found on the web are ahead of the curve, offering all natural products to help with soft tissue calcification.
The most reputable protocols seem to involve a step wise system that entails some type of chelating action followed by balancing the body’s minerals and helping the body’s natural calcium “helpers” make sure that calcium (and other minerals) is used correctly, and in the right parts of the body, i.e., the bones. Some web sites I visited also encouraged the use of antioxidants that help to neutralize free radical damage.
As more data regarding soft tissue calcification is accepted by the medical community, the diagnosis and treatments will become more available. I will continue to post updates regarding STC and various treatment options.
Historically, health care practitioners have mainly considered the process of STC to be passive and secondary to many of the disease in which it is associated. Mounting research, however is begging to paint a new picture wherein STC may actually be the cause of many diseases. A recent study by the Department of Nephrology and Clinical Immunology in Aachen, Germany states that “calcification at unwanted tissue sites leads to dysfunction, disease and, potentially, to death and therefore requires prevention and treatment.” Why?
The health harards regarding STC are not limited to the fact that calcium phosphate deposition hardens our soft tissues, making them rigid and sometimes painful as in arthritis, but also that the calcium phosphate matrix is literally a bioactive substrate laying in wait to turn on some of your bodies most dangerous proteins and to use them against you.
Consider this: there are over 3000 calcium binding proteins in your body that travel through the circulatory and lymphatic system. These proteins rely on the binding of calcium in order to become active and perform its specific function. Many of these calcium binding proteins have extremely important tasks including precursors for inflammation, clotting, and other immunologic functions. The first large scale proteomic mapping of atherosclerotic plaques was recently completed at the University of Connecticut. The study, due to publish in May 2007, is reported to show various new proteins associated with plaque.
A recent study conducted at Baylor College, Department of Medicine, TX wherein researchers evaluated carotid plaque showed a direct correlation between the degree of calcification of the plaque and the proteins therein. Basically, they proved that the more calcification, the more proteins. A study published by the American Heart Association showed, definitively, the active inflammatory response by macrophages to basic calcium phosphate crystals and its implications for atherosclerosis and pathogenesis. Still another study from 2005 linked elevated calcium phosphate (calcification) to elevated High C-reactive protein (common marker for inflammation) concentrations in 47 uremic patients.
STC has been linked to many disease states, including: Alzheimer’s, Arthritis, Bone spurs, Breast calcification, Calcinosis cutis (calcium deposits in the skin), Cancer (bone, brain, breast, colon, prostate, and ovarian), Cataracts, Deafness from middle ear ossification, Diabetes, Gallstones, Glaucoma, Heart disease, notably arteriosclerosis and atherosclerosis, Kidney stones, cysts, polycystic kidney disease (PKD), Liver cysts, Macular degeneration, Meniere’s disease, Prostatitis, Psoriasis, Salivary gland stones, Sclerderma (hardening of the skin), Stroke, Tendinitis.
So why has the link between Calcification and inflammation/disease state not been addressed more aggressively in this country?
Perhaps it’s due to the inherent resistance within the medical community to change, or that a large Pharma company has not spent billions on marketing a drug to address STC? Perhaps it’s the fact that medical science may not know how to address STC?
Regardless, there ARE steps one can take to help address STC, and the most headway in this area seems to be taking place in the realm of dietary supplements.
Available, packaged treatments for soft tissue calcification are relatively rare right now; however there are a couple companies that offer treatments. They range from compounded pharmaceuticals to specialty, condition specific dietary supplements. A handful of companies found on the web are ahead of the curve, offering all natural products to help with soft tissue calcification.
The most reputable protocols seem to involve a step wise system that entails some type of chelating action followed by balancing the body’s minerals and helping the body’s natural calcium “helpers” make sure that calcium (and other minerals) is used correctly, and in the right parts of the body, i.e., the bones. Some web sites I visited also encouraged the use of antioxidants that help to neutralize free radical damage.
As more data regarding soft tissue calcification is accepted by the medical community, the diagnosis and treatments will become more available. I will continue to post updates regarding STC and various treatment options.
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